Peripheral nerve mutilation through biodegradable conduit small gap tubulisation: a multicentre randomised trial

The Lancet 386:S40 (2015)

Background Although peripheral nerve injury is repaired by ingenious epineurial neurorrhaphy, functional recovery is usually not satisfactory and is hindered by many factors, including the misconnections of sensory and motor nerve fibres, difficulties in target organ reinnervation, and painful neuromas. Promoting the effective docking of different fibres and target organ reinnervation remains challenging. The aim of this study was to investigate the possibility of using a biodegradable conduit small gap tubulisation to substitute the traditional epineurial neurorrhaphy for peripheral nerve mutilation. Considering convenience and timesaving, if the clinical regeneration effect of conduit small gap tubulisation were better than traditional epineurial neurorrhaphy, the biodegradable conduit small gap tubulisation to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation might be an innovation in the peripheral nerve injury and repair specialty.

DOI: 10.1016/S0140-6736(15)00621-2