Timeline: Checkpoint Blockade

Cell 162(6):1434 (2015) PMID 26359994

Immune checkpoint therapy, targeting inhibitory pathways in T cells to unleash antitumor immune responses, has led to amazing advances in the clinical care of patients with highly aggressive and otherwise-untreatable cancers. Paraphrasing Jim Allison, the recipient of the 2015 Lasker-DeBakey Clinical Medical Research Award, before we were able to successfully use the immune system to treat cancer, we had to understand the inner workings of the immune response. This timeline highlights key contributions over the past 30 years that constituted essential steps toward the concept of immune checkpoint therapy.

DOI: 10.1016/j.cell.2015.08.019